Endocrine Abstracts

Objective: Acromegaly is associated with increased cardiovascular mortality. Hyperhomocysteinemia has been associated with cardiovascular disease, lower-extremity peripheral arterial disease and heart failure. Data on the prevalence of hyperhomocysteinemia and peripheral arterial disease in patients with acromegaly is still limited. The aim of this study was to compare serum homocysteine levels between acromegaly patients with active disease and remission, and to evaluate pres...

Aim: The aim was to assess the expressions of GLP-1, IGF-1 and leptin in the paraffin sections of operated thyroid cancer and non-thyroid cancer patients, and show the relationship of GLP-1, IGF-1 and leptin receptor expressions with thyroid cancer, comparatively.Materials and Methods: This study was carried out retrospectively. The case groups consisted of 20 medullary thyroid cancer (MTC), 20 follicular thyroid cancer (FTC), 20 classical papillary thyr...

Objective: To evaluate the presence of glucose metabolism abnormalities and their impact on IGF-1 levels in patients with acromegaly.Methods: Ninety-three acromegalic patients (52 male/41 female) were included in this study who were seperated into three groups as normal glucose tolerance (NGT), prediabetes and diabetes mellitus (DM). Insulin resistance (IR) was calculated with homeostasis model assessment (HOMA). HOMA-IR >2.5 or ≤2.5 were defin...

Hypothyroidism is a common endocrine disorder which is easily treatable by an appropriate thyroid hormone replacement therapy in the majority of patients. In some patients, hypothyroidism is refractory to oral levothyroxine substitution. Common causes of lack of response to levothyroxine replacement comprise non-compliance and impaired absorption. We report a case of pseudomalabsorption of levothyroxine. Here, we report two female patients with hypothyroidism who had multinod&...

Objective: The aim of the study is to evaluate both the long-term consequences of exposure to dopamine agonists (CAB and BRC) at the beginning and during pregnancy, and the effects of pregnancy on remission.Methods: Thirty-seven prolactinoma patients who developed 58 pregnancies while receiving DAs treatment were included in this retrospective study. Age of gestation; both maximum residual tumor diameter and PRL levels before conception; the course of pr...

Purpose: Somatotrophinomas have been shown to demonstrate T2-weighted signal intensity (WSI) on MRI that is correlated with clinicopathological findings and response to treatment. Therefore, we aimed to investigate these correlations in functional pituitary adenomas, including prolactinoma and corticotrophinoma. Material and MethodsPatients with somatotrophinoma (n=87), prolactinoma (n=78) and corticotrophinoma (n=33) were invo...

Introduction: Hirsutism affects 5–8% of the whole female population. In most patients, hirsutism is associated with hyperandrogenemia and the most common cause of androgen excess is polycystic ovary syndrome; however, the clinical presentation of non-classical congenital adrenal hyperplasia(NCAH) in females is often indistinguishable from other hyperandrogenic disorders because of common clinical signs with hirsutism and poly cystic ovary syndrome(PCOS).<p class="abst...

A 41-year-old woman was admitted with headache and hypertension. She described worsening of headaches in the last 2 months. On physical examination blood pressure was 150/90 mmHg, and grade 1 hypertensive retinopathy was present. Her sister died at the age of 24 due to pancreas neuroendocrine tumour and her mother was followed up with multiple pancreatic cysts. Abdomen MRI revealed a 6 cm phaeochromocytoma lesion on the right surrenal and multiple cysts in the pancreas, kidney...

Propylthiouracil (PTU) is a widely used drug, and can cause drug-induced vasculitis which is characterized by inflammation and cellular infiltration of small vessels and presence of anti-neutrophil cytoplasmic antibodies (ANCA). We report a case of perinuclear antineutrophil cytoplasmic antibody-associated vasculitis developed during treatment with PTU for Graves’ disease. A 58-year-old woman admitted to the Emergency Department with painful necrotic lesion at her right e...

Oncogenic osteomalacia is a rare paraneoplastic syndrome, which can be associated with phosphaturic mesenchymal tumor or non-mesenchymal tumour. This tumour produces fibroblast growth factor 23 (FGF-23) that leads to subsequent hypophosphataemic osteomalacia. We, hereby present a patient with oncogenic osteomalasia who is misdiagnosed as ankylosing spondylitis. A 54-year old man with weakness, severe arthralgia involving pelvis, hip joints and lower extremities referred to the...